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There are several matches for 'Error-prone DNA polymerase'.
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10675 matches
showing page 1 of 534
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organism
protein
1)
Homo sapiens
POLI -
DNA
polymerase
iota;
Error
-
prone
DNA
polymerase
specifically involved in
DNA
repair. Plays an important role in translesion synthesis, where the normal high-fidelity
DNA
polymerases
cannot proceed and
DNA
synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but [...]
[a.k.a. UPI00004DDD95, AC093462, NM_001351620.2]
2)
Homo sapiens
REV3L -
DNA
polymerase
zeta catalytic subunit; Catalytic subunit of the
DNA
polymerase
zeta complex, an
error
-
prone
polymerase
specialized in translesion
DNA
synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
[a.k.a. NP_002903, ENST00000358285, ENSP00000352783]
3)
Homo sapiens
PRIMPOL -
DNA
-directed primase/polymerase protein;
DNA
primase and
DNA
polymerase
required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo
DNA
synthesis using dNTPs and acting as an
error
-
prone
DNA
polymerase
able to bypass certain
DNA
lesions. Shows a high capacity to tolerate
DNA
damage lesions such as 8oxoG and abasic sites in
DNA
. Provides different translesion synthesis alternatives when
DNA
replication is stalled: able to synthesize
DNA
primers downstream of lesions, such as ultr [...]
[a.k.a. NP_001287697.1, Primase and DNA directed polymerase, 201973]
4)
Homo sapiens
MAD2L2 - Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the
error
-
prone
DNA
polymerase
zeta catalytic subunit REV3L and the inserter
polymerase
REV1, thereby mediating the second
polymerase
switching in translesion
DNA
synthesis. Translesion
DNA
synthesis releases the replication blockade of replicative
polymerases
, stalled in presence of
DNA
lesions. Component of the shieldin complex, which plays an important role in repair of
DNA
double-stranded breaks [...]
[a.k.a. MAD2L2-206, ENST00000376655, 5XPU]
5)
Homo sapiens
POLN -
DNA
polymerase
nu;
DNA
polymerase
with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the
DNA
polymerase
A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion
DNA
synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity.
Error
-
prone
DNA
polymerase
that preferentially misincorporates dT regardless of templ [...]
[a.k.a. ENST00000508568, ENST00000511777, DNA polymerase nu]
6)
Homo sapiens
POLQ -
DNA
polymerase
theta;
DNA
polymerase
that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in
DNA
. MMEJ is an
error
-
prone
repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. POLQ-mediated MMEJ may be required to promote [...]
[a.k.a. URS0000EB76BA, 4X0P, NP_955452]
7)
Mus musculus
Poli -
DNA
polymerase
iota;
Error
-
prone
DNA
polymerase
specifically involved in
DNA
repair. Plays an important role in translesion synthesis, where the normal high-fidelity
DNA
polymerases
cannot proceed and
DNA
synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template (By similarity). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (By similarity). May play a role in hypermutation of immunogobulin genes (By similarity). Forms a Schiff base wit [...]
[a.k.a. ENSMUST00000160713, XM_011246934.2, ENSMUSP00000039869]
8)
Mus musculus
Rev3l -
DNA
polymerase
zeta catalytic subunit; Catalytic subunit of the
DNA
polymerase
zeta complex, an
error
-
prone
polymerase
specialized in translesion
DNA
synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function; Belongs to the
DNA
polymerase
type-B family.
[a.k.a. ENSMUSP00000115630, Sez4, ENSMUST00000127726.1]
9)
Mus musculus
Primpol -
DNA
-directed primase/polymerase protein;
DNA
primase and
DNA
polymerase
required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo
DNA
synthesis using dNTPs and acting as an
error
-
prone
DNA
polymerase
able to bypass certain
DNA
lesions (By similarity). Shows a high capacity to tolerate
DNA
damage lesions such as 8oxoG and abasic sites in
DNA
(By similarity). Provides different translesion synthesis alternatives when
DNA
replication is stalled: able to synthesize
DNA
primers dow [...]
[a.k.a. BC065112, AC138367, AK030772]
10)
Mus musculus
Mad2l2 - Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the
error
-
prone
DNA
polymerase
zeta catalytic subunit REV3L and the inserter
polymerase
REV1, thereby mediating the second
polymerase
switching in translesion
DNA
synthesis. Translesion
DNA
synthesis releases the replication blockade of replicative
polymerases
, stalled in presence of
DNA
lesions. Component of the shieldin complex, which plays an important role in repair of
DNA
double-stranded breaks [...]
[a.k.a. G1-453-4, ENSMUST00000140049.7, ENSMUSP00000081146]
11)
Mus musculus
Poln -
DNA
polymerase
nu;
DNA
polymerase
with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the
DNA
polymerase
A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion
DNA
synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity.
Error
-
prone
DNA
polymerase
that preferentially misincorporates dT regardless of templ [...]
[a.k.a. POL4P, Poln-207, DNA polymerase nu]
12)
Mus musculus
Polq -
DNA
polymerase
theta;
DNA
polymerase
that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in
DNA
. MMEJ is an
error
-
prone
repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. POLQ-mediated MMEJ may be required to promote [...]
[a.k.a. Polq-205, UPI00000E8E5A, AC154763]
13)
Drosophila melanogaster
DNApol-iota -
DNA
polymerase
iota;
Error
-
prone
DNA
polymerase
specifically involved in
DNA
repair. Plays an important role in translesion synthesis, where the normal high-fidelity
DNA
polymerases
cannot proceed and
DNA
synthesis stalls. Favors Hoogsteen base-pairing in the active site (By similarity). Inserts the correct base with higher fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
[a.k.a. FBgn0037554, DNApol-iota-PB, DNApol-iota-PC]
14)
Drosophila melanogaster
DNApol-eta - DNApol-eta;
DNA
polymerase
specifically involved in the
DNA
repair by translesion synthesis (TLS). Plays an important role in translesion synthesis, where the normal high-fidelity
DNA
polymerases
cannot proceed and
DNA
synthesis stalls. Inserts one or 2 nucleotide(s) opposite the lesion. During homologous recombination (HR) repair, has a overlapping role with the
error
-
prone
translesion
polymerase
DNApol-zeta/DNApolZ1 to initiate repair synthesis that is completed by end joining or another
polymerase
that can bind and reinitiate synthesis. Particularly important for the repair of UV-in [...]
[a.k.a. FBgn0037141, DNApol-eta-PA, POLH_DROME]
15)
Drosophila melanogaster
DNApol-zeta -
DNA
polymerase
zeta catalytic subunit; As the catalytic subunit of the
DNA
polymerase
zeta complex, plays a crucial role in translesion
DNA
synthesis (TLS) and various
DNA
repair mechanisms. Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. During homologous recombination (HR) repair, has a overlapping role with the
error
-
prone
translesion
polymerase
eta to initiate repair synthesis which is completed by end joining or another
polymerase
that can bind and reinitiate synthesis. May participate in the Rrp1- dependent base excision repair (BER) pathway r [...]
[a.k.a. FBgn0002891, DNApol-zeta-PA, 47186]
16)
Caenorhabditis elegans
polq-1 -
DNA
polymerase
theta;
DNA
polymerase
that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in
DNA
. MMEJ is an
error
-
prone
repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Required to prevent extensive loss of sequences near G-quadruplex (G4)
DNA
sites, which are
prone
to cause genome alterations, by generating deletions.
[a.k.a. W03A3.2, WBGene00020964, NP_498250.3]
17)
Escherichia coli K12
umuC - Translesion
error
-
prone
DNA
polymerase
V subunit; Involved in UV protection and mutation. Poorly processive,
error
-
prone
DNA
polymerase
involved in translesion repair. Essential for induced (or SOS) mutagenesis. Able to replicate
DNA
across
DNA
lesions (thymine photodimers and abasic sites, translesion synthesis) in the presence of activated RecA; efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of
DNA
polymerase
III plus single-stranded binding protein (SSB). RecA and to a lesser extent the beta clamp- complex may target Pol V to replication co [...]
[a.k.a. AAC74268.1, b1184, Protein UmuC]
18)
Escherichia coli K12
umuD - Translesion
error
-
prone
DNA
polymerase
V subunit; Involved in UV protection and mutation. Poorly processive,
error
-
prone
DNA
polymerase
involved in translesion repair. Essential for induced (or SOS) mutagenesis. Able to replicate
DNA
across
DNA
lesions (thymine photodimers and abasic sites, called translesion synthesis) in the presence of activated RecA; efficiency is maximal in the presence of the beta sliding-clamp and clamp-loading complex of
DNA
polymerase
III plus single-stranded binding protein (SSB). RecA and to a lesser extent the beta clamp-complex may target Pol V to replicat [...]
[a.k.a. b1183, AAC74267.1, P0AG11]
19)
Escherichia coli K12
dinB -
DNA
polymerase
IV; Poorly processive,
error
-
prone
DNA
polymerase
involved in translesion repair and untargeted mutagenesis. Copies undamaged
DNA
at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by Pol IV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of Pol IV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long- term survival and evol [...]
[a.k.a. b0231, DinB, 4Q44]
20)
Saccharomyces cerevisiae
POL32 - Third subunit of
DNA
polymerase
delta; involved in chromosomal
DNA
replication; required for
error
-
prone
DNA
synthesis in the presence of
DNA
damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p.
[a.k.a. YJR043C, AAA88745.1, NM_001181701]
10675 matches
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